Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Traumatic brain injury (TBI) continues to be a major contributor morbidity, disability, and mortality in all age groups. Initial damage is accompanied by acute irreversible primary the parenchyma, while subsequent secondary often progresses slowly over months years, thus providing window for therapeutic intervention. The most frequent case which happened excessive oxidative stress calcium release after injury. Although some traditional antioxidants have been clinically approved, efficacy far from satisfactory due their low ROS-scavenging efficiency, instability, toxicity, or inadequate penetration of blood-brain barrier. Moreover, combination Nanozyme based-bandage with Pt/CeO2 atom catalysis electrospinning nanofibers N-type voltage-gated channel blocker (SNX-185) predicted as promising potential novel reduce TBI. Therefore, duo could cut down morbidity rates because TBI future, noninvasively.